DSPE-PEG(2000) Maleimide - Names and Identifiers
DSPE-PEG(2000) Maleimide - Physico-chemical Properties
DSPE-PEG(2000) Maleimide - Introduction
DSPE-PEG-MAL(DSPE-PEG-MAL) is a functional phospholipid covalently modified polyethylene glycol (PEG) derivative. The following is a description of the nature, use, formulation and safety information of the DSPE-PEG-MAL:
Nature:
- DSPE-PEG-MAL is a white solid with good solubility at room temperature.
-It has excellent biocompatibility and water solubility, and can be effectively metabolized and excreted by organisms.
- DSPE-PEG-MAL has good stability and controllable surface chemical properties, and has a high affinity for other biological macromolecules.
Use:
- DSPE-PEG-MAL is mainly used for the preparation of nanoparticles and nanocarriers. It can be used as a surface modifier to encapsulate and stabilize drug delivery systems such as drugs, proteins and nucleic acids to achieve drug delivery and release.
-It can also be used in the preparation of biosensors, fluorescent probes, molecular imaging and targeted therapy applications.
Preparation Method:
The preparation of DSPE-PEG-MAL is generally divided into two steps:
1. Synthesis of maleimide-phospholipid (MAL-DSPE): Maleimide-phospholipid is obtained by reacting maleimide with phospholipid under appropriate conditions.
2. Linking polyethylene glycol (PEG): A maleimide-phospholipid is reacted with polyethylene glycol under appropriate conditions to obtain a DSPE-PEG-MAL.
Safety Information:
-When using DSPE-PEG-MAL, you should follow the general safety procedures for chemicals, such as wearing chemical protective gloves, operating outside the laboratory, and avoiding contact with skin and inhalation of dust particles.
- DSPE-PEG-MAL is generally used in the field of biomedicine, and related clinical trials are still in progress. Before using this substance, carefully evaluate the toxicity and biocompatibility of the drug to ensure that it is used in appropriate amounts and under appropriate conditions.
-When it comes to use in humans, its potential toxicity and biological safety need to be further evaluated. Adequate validation and testing is required prior to use.
Last Update：2024-04-09 02:00:49